Centrolenidae are commonly found in tropics such as the Amazon rainforest, along with other locations within South and Central America. Within their forests, glass frogs tend to live near running water; as they are aquatic early on in their life cycle. These frogs are arboreal, meaning they spend nearly all their adult life in trees, where their adaptations can disguise them perfectly. As a carnivore that feeds on insects, Centrolenidae are necessary to keep down insect populations within the ecosystem (Naiche). On the other hand, their own population is kept in check due to their abundance and small size, often becoming targets for snakes and birds. Glass frogs are most active at night until sunrise, where the shadows provide camouflage while the frogs hunt prey. While their nocturnal behavior is not unique, their ability to stay unnoticed in the dark is unparalleled. Glass frogs flatten their bodies against leaves when predators are around, minimizing the chances that their already-camouflaged bodies are looked at. When combined with the darkness and their color, they are near impossible to find in the dark.
Glass frogs flatten their bodies when a treat is nearby.